Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

By M. Brunkow, E. Jeffery, Kathryn A. Hjerrild, B. Paeper, Lisa B. Clark, Sue-Ann Yasayko, J. Wilkinson, D. Galas, Steven F. Ziegler, F. Ramsdell. Nature Genetics, 2001

2,871 citations recorded by the source corpus.

Subfields: Immunology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/ce001fb429a98e3a39375d3c7cfca82c71078424

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Nutrition and Dietetics

Guido Kroemer

Citations in the corpus

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 (2007, methodology): “The foxp3 transgenic mice were generated as described (18) and provided by Dr.”
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease (2007, background): “These mice, which suff er from a fatal lymphoproliferative disorder, harbor a mutated foxp3 gene coding for a product that lacks the forkhead domain (13).”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “Scurfin was later found to be the transcription factor, Foxp3 (67, 82).”
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 (2003, background): “In exciting new papers, Foxp3 , which encodes a transcription factor that is genetically defective in an autoimmune syndrome in humans and mice (11, 12), has been shown to be not only specifically expressed in professional T reg , but also required for their development (13–15).”
Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression (2011, background): “Loss of function mutations of the Foxp3 gene in both mice and humans results in fatal autoimmunity affecting multiple organ systems, and depletion of the Foxp3+ Treg population in adult mice was also found to result in severe and fatal full-body autoimmunity (30-32).”
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways (2008, background): “The deletion of Tregs leads to multi-organ autoimmunity (83).”
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation (2005, background): “They represent 1–3% of CD4 T cells in humans and 5–10% of CD4 T cells in rodents and express cell surface molecules associated with activated/ memory cells (CD25, CD45Rb low , CD62L, CD103, CTLA4, and GITR), as well as the pathognomonic transcription factor protein Foxp3 (3).”
Regulatory T cells and immune tolerance. (2008, background): “Surfy is an X-linked recessive mutant that is lethal in hemizygous males within a month after birth, exhibiting hyperactivation of CD4+ T cells and overproduction of proinflammatory cytokines (Brunkow et al., 2001).”