The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

By P. Dumont, J. Leu, Anthony Della Pietra, D. George, M. Murphy. Nature Genetics, 2003

1,337 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/cd8e3e284d4692ebb27ff39ee301c1fcb1eb79f8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Angelina V. Vaseva
2. Magali Olivier
3. Pierre Hainaut
4. U. Moll

In Molecular Biology

1. Magali Olivier
2. Pierre Hainaut
3. Angelina V. Vaseva
4. Y. Bae
5. M. Guo
6. Hyunjin Oh
7. Haolan Wang
8. Yongheng Chen

In Oncology

1. Magali Olivier
2. Pierre Hainaut
3. Angelina V. Vaseva
4. M. Guo
5. Haolan Wang
6. Yongheng Chen
7. U. Moll
8. Hudie Wei

Citations in the corpus

• Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “The proline-rich region linking the TAD to DBD is required for p53 to induce cell cycle arrest and apoptosis.(278,279) This region plays a role in signal transduction by binding to Src homology 3 domains.”
• The mitochondrial p53 pathway (2008, positive): “In addition to localizing to the outer membrane (described above), a subfraction of p53 localizes inside mitochondria and complexes with the major mitochondrial import proteins mthsp70 and mthsp60, present in the matrix [7,51].”
• p53 polymorphisms: cancer implications (2009, neutral): “i1 i2 i3 i4 i5 i6 i7 i8 i9 i10 (41, 10,739) (1, 115) (2, 92) (5, 775) (2, 81) (4, 567) (7, 342) (1, 92) (13, 2,817) (5, 919) Transactivation domains Prolinerich domain DNA-binding domain Tetramerization domain”
• Regulation of reactive oxygen species generation in cell signaling (2011, background): “…mitochondrial membrane in response to a variety of stress signals, including DNA damage and hypoxic stress, and promotes transcription-independent p53-mediated cell death (Chipuk et al., 2004; Dumont et al., 2003; Mihara et al., 2003; Pim and Banks, 2004; Sansome et al., 2001; Yoo et al., 2005).”
• TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes (2007, background): “Arg72 was shown to be more efficient in inducing apoptosis, a property that correlated with a greater capacity to interact with MDM2 which facilitate nuclear export and mitochondrial localization (Dumont et al., 2003).”