The mitochondrial p53 pathway
By Angelina V. Vaseva, U. Moll. Biochimica et Biophysica Acta, 2008
616 citations recorded by the source corpus.
p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. For a long time it was thought that these functions of p53 solely rely on its function as a transcription factor, and numerous p53 target genes have been identified [1]. In the last 8 years however, a novel transcription-independent proapoptotic function mediated by the cytoplasmic pool of p53 has been revealed. p53 participates directly in the intrinsic apoptosis pathway by interacting with the multidomain members of the Bcl-2 family to induce mitochondrial outer membrane permeabilization. Our review will discuss these studies, focusing on recent advances in the field.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/a73227301d464c5395e04fe9d321ba2077717abc
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Moshe Oren
- Arnold J. Levine
- Angelina V. Vaseva
- Nektarios Tavernarakis
- A. Gorman
- U. Moll
- Simone Fulda
- Afshin Samali
In Oncology
- Moshe Oren
- Arnold J. Levine
- Angelina V. Vaseva
- A. Gorman
- U. Moll
- Simone Fulda
- Afshin Samali
- Carol Prives
Citations in the corpus
- Crosstalk between apoptosis, necrosis and autophagy. (2013, background): “Upon stress, a cytoplasmic pool of p53 rapidlytranslocatestothemitochondrialsurface,whereit physically interacts with both anti-and pro-apoptotic BCL-2 family members to inhibit or activate their respective functions, leading to MOMP and apoptosis [57].”
- The first 30 years of p53: growing ever more complex (2009, positive): “A detailed account of these additional p53 activities is not in the scope of this article; however, most notable among them is the ability of p53 to interact in the cytoplasm with members of the Bcl2 family of apoptosis-regulatory proteins, thereby directly contributing to mitochondrial outer membra”
- p53 opens the mitochondrial permeability transition pore to trigger necrosis (2012, background): “Since both p53 and mPT play important roles during oxidative stress (Gudkov and Komarova, 2010; Halestrap, 2006; Vaseva and Moll, 2009), we looked for an interaction between p53 and the PTP components CypD, ANT, and VDAC upon H2O2 treatment.”
- Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “The pharmacological action of Nutlin-3 is through both the transcription-dependent and independent p53 apoptotic pathways [128,146,147].”
- Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “In addition, recent studies have also defined a nontranscriptional pro-apoptotic activity of p53 that regulates the intrinsic mitochondriamediated pathway of apoptosis [180].”