Intraflagellar transport

By J. Rosenbaum, G. Witman. Nature reviews. Molecular cell biology, 2002

1,453 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cd8893f60045abddbea33775d72540438a5feb1f

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Citations in the corpus

The graded response to Sonic Hedgehog depends on cilia architecture. (2007, background): “Cilia depend on intraflagellar transport (IFT) proteins for their assembly and maintenance (Scholey, 2003), and the ability to respond to Hedgehog ligands is lost in embryos that lack any one of six different IFT proteins (Houde et al.”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “In this subsubsection we review only intraflagellar transport (IFT) [772, 773, 774, 775, 776, 777, 778, 779, 780], a phenomenon that is driven by molecular motors, that has a much shorter history [781].”
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis (2005, background): “Our insight into cilia assembly has been significantly advanced by the discovery of the cellular machinery responsible for moving particles along the microtubule scaffold of cilia or flagella, called intraflagellar transport (IFT) (Rosenbaum and Witman, 2002).”
Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function (2005, background): “Cilia are microtubule-based organelles that protrude from the surface of most cells in the mammalian body and are formed through a conserved process termed intraflagellar transport (IFT) [1].”
Non‐syndromic retinitis pigmentosa (2018, neutral): “, retrograde transport, which is driven by dynein motor proteins) (Rosenbaum and Witman, 2002; Scholey, 2003; Wren et al., 2013).”
Proteomic analysis of a eukaryotic cilium (2005, background): “Defects in cilia in humans have long been known to cause the severe inherited disorder primary ciliary dyskinesia; more recent evidence has implicated cilia in polycystic kidney disease (PKD), retinal degeneration, obesity syndromes, and developmental disorders (Pazour and Rosenbaum, 2002; Ong and W”
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. (2010, positive): “The heterotrimeric KIF3 complex (KIF3A/KIF3B/KAP3) bimodally functions in intraflagellar transport (IFT) of ciliary components (Rosenbaum and Witman, 2002) and in axonal or intracellular transport of plasma membrane precursors (Takeda et al., 2000) and the N-cadherin/b-catenin complex (Teng et al.,…”
Overview of structure and function of mammalian cilia. (2007, background): “Rosenbaum and collaborators (40), through their work with Chlamydomonas, first envisioned and analyzed the molecular basis of the transport process.”
The conserved Bardet-Biedl Syndrome proteins assemble a coat that traffics membrane proteins to cilia (2010, positive): “The delivery of membrane proteins to cilia sequentially entails sorting and packaging into carrier vesicles, docking, and fusion of vesicles with the base of the cilium and intraflagellar transport (IFT) from cilia base to cilia tip (Rosenbaum and Witman, 2002).”
Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex (2022, background): “Due to the vital role of IFT in ciliogenesis and maintenance, variants in genes encoding IFT proteins are commonly linked to ciliopathies (21).”