The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

By Günter P. Wagner, Jianzhi Zhang. Nature reviews genetics, 2011

673 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cd25404078b6c96f3e83d81a3fef4c75aec7d996

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Citations in the corpus

Empirical fitness landscapes and the predictability of evolution (2014, background): “The first‐order coefficient a((1)) describes the linear, non‐epistatic effects, the second‐order coefficient a((2)) denotes pairwise epistatic interactions and so on.”
Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene (2013, background): “Developmental and systems biologists seek to understand the physical, biochemical, and physiological causes of epistasis, whereas evolutionary biologists study its evolutionary consequences (Costanzo et al. 2010; de Visser et al. 2011; Lehner 2011; Wagner and Zhang 2011).”
An expanded view of complex traits: from polygenic to omnigenic (2017, background): “Mendelian Randomization generally assumes that pleiotropy between traits that are not causally related—also referred to as ‘‘type I pleiotropy’’ (Wagner and Zhang, 2011)—is rare.”
Evaluating the potential role of pleiotropy in Mendelian randomization studies (2018, background): “ropy, though it has also been called biological pleiotropy (106), Type I pleiotropy (107), developmental pleiotropy and selec-”
Network biology concepts in complex disease comorbidities (2016, neutral): “…genetic • Developmental • Selectional Biological • Developmental • Selectional • Artefactual • Unifying Paaby and Rockman 2013 Phenotype Function Gene product Gene Mutation Wagner and Zhang 2011 Hodgkin 1998 Solovieff et al. 2013 MediatedBiological Figure 3 | Five models of…”
Constraints Evolve: Context Dependency of Gene Effects Allows Evolution of Pleiotropy (2015, background): “Even if the position of the trait axes may be arbitrary (discussed in Mitterocker et al. 2012, Wagner & Zhang 2011), and hence the trait can be defined to be parallel to a mutation, the change in the angle of the mutation vector changes pleiotropy.”
The genomics of local adaptation in trees: are we out of the woods yet? (2017, background): “…mutations, the former of which is ultimately determined by the direction and size of effect among a set of pleiotropic loci across a set of characters (see Arnold 1992; Wagner & Altenberg 1996; Hansen 2003, 2006; Wagner et al. 2007; Chevin et al. 2010b; Wagner & Zhang 2011; MacPherson et al. 2015).”
Mendelian randomization: genetic anchors for causal inference in epidemiological studies (2014, background): “Whereas factorial MR can be applied to multiphenotype relationships when different SNPs can be taken to be instrumental variables for each phenotype, in this case, this is not possible because constructing an instrument that purely relates to one phenotype is currently not possible.”