Empirical fitness landscapes and the predictability of evolution

By De Visser, Joachim Krug. 2014

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Adaptation in protein fitness landscapes is facilitated by indirect paths (2016, background): “(B) The WT sequence of the nucleotide template [33].”
A model of substitution trajectories in sequence space and long-term protein evolution. (2015, background): “Whether or not epistasis, a situation when ﬁtness is dependent on the interaction of alleles, plays a major role in molecular evolution is the subject of scrutiny and debate (de Visser et al. 2011; Lehner 2011; Breen et al. 2012; Hansen 2013; McCandlish et al. 2013; de Visser and Krug 2014).”
Predicting evolution (2017, background): “The latter are dominated by ‘microscopic’ epistasis, which decreases the number of accessible evolutionary paths 66,72 , but the local peaks and valleys in a given system can hardly be captured by a predictive model with few parameters 70,77–80 .”