Protein kinase C and other diacylglycerol effectors in cancer

By Erin M. Griner, M. Kazanietz. Nature Reviews. Cancer, 2007

1,005 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008, background): “Oncogene Protein kinases C can have a dual function in apoptosis, that is, the activation of specific PKC isoforms may protect or induce cell death, often in a cell-type-specific manner (Lavin et al., 1996; Liu et al., 2002; Griner and Kazanietz, 2007).”
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling (2008, background): “Protein kinase C (PKC) is one of the most extensively studied kinase family and has been implicated in cell proliferation, differentiation, apoptosis, tumour promotion and neuronal activity (Griner and Kazanietz, 2007).”
Structural Basis of Protein Kinase C Isoform Function (2008, background): “General reviews that examine the physiological consequences of PKC isoform activation in individual tissues have appeared elsewhere (21, 71, 119, 137, 139, 201, 230); these topics are beyond the scope of this review and will not be covered.”
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications (2020, background): “The family of PKC contains 12 isoforms, in which PKC-α, -β, -δ, and -ε has been reported to be activated during the development of DR [57,58].”