Generation of cerebral organoids from human pluripotent stem cells

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Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, neutral): “, 2013), neurons (Hoelting et al., 2013; Lippmann et al., 2014; Lancaster and Knoblich, 2014; Terrasso et al., 2015; Simão et al., 2016), lung (Ghaedi et al.”
Brain organoids: advances, applications and challenges (2019, methodology): “…Stationary floating culture, followed by re-plating of aggregates Eiraku et al., 2008 Cerebral organoid Whole brain Unguided Spinning bioreactor Lancaster and Knoblich, 2014; Lancaster et al., 2013 Cortical neuroepithelium Cerebral cortex Guided Floating culture in 40% oxygen, permeable…”
Complex oscillatory waves emerging from cortical organoids model early human brain network development (2019, background): “Organoids generated from induced pluripotent stem cells (iPSCs) have emerged as a scaled-down and three-dimensional model of the human brain, mimicking various developmental features at the cellular and molecular levels (Camp et al., 2015; Cederquist et al., 2019; Giandomenico et al., 2019; Lancaste”
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development (2015, methodology): “The protocol to grow cerebral organoids was designed to mimic early stages of forebrain development and then rely on the intrinsic self-organizational capacity of the cells to pattern, specify, and generate structured cerebral tissue (11).”