Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
By J. G. Camp, F. Badsha, Marta Florio, Sabina Kanton, Tobias Gerber, Michaela Wilsch‐Bräuninger, E. Lewitus, A. Sykes, W. Hevers, Madeline A. Lancaster and 5 more. Proceedings of the National Academy of Sciences of the United States of America, 2015
1,029 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0c3545bc28f5211e6508b420312f2f04d9a68438
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Citations in the corpus
- Modeling Development and Disease with Organoids. (2016, background): “A subsequent study applied single-cell RNA sequencing to compare gene expression programs of cells within cerebral organoids to those of fetal human neocortex development (Camp et al., 2015).”
- Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3 (2016, positive): “Several groups have developed cerebral organoidmodels that generate functional cortical neurons and can recapitulate forebrain, midbrain, and hindbrain regions with functional electrophysiological properties to probe the mechanisms of neurodevelopment, autism, and microcephaly (Camp et al., 2015; Ei”
- Cell diversity and network dynamics in photosensitive human brain organoids (2017, result): “In agreement with prior work that had examined a smaller number of cells from early-stage organoids 17 , the cells generated are closely related to their endogenous counterparts of the brain and retina.”
- Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin producing neurons (2016, background): “When neuroectodermal buds were starting to extrude, the hMLOs were embedded in 30 mL of reduced growth factor Matrigel and grown in tissue growth induction medium containing 100 ng/mL SHH-C25II and 100 ng/mL FGF8.”
- Brain organoids: advances, applications and challenges (2019, background): “They exhibit a variety of cell lineage identities ranging from forebrain, midbrain and hindbrain, to retina, choroid plexus and mesoderm (Camp et al., 2015; Lancaster et al., 2013).”
- Splatter: simulation of single-cell RNA sequencing data (2017, background): “Camp [44] Human Whole brain organoids Fluidigm C1 SMARTer No 597”