Placental development: Lessons from mouse mutants

By Janet Rossant, J. Cross. Nature reviews genetics, 2001

1,322 citations recorded by the source corpus.

Subfields: Molecular Biology, Obstetrics and Gynecology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/cba0ec7fb598f1fc89b93d10015cbee01e977e81

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In Molecular Biology

1. Richard A. Young
2. Janet Rossant
3. A. Moffett-King
4. David A. Orlando
5. Y. Yamanaka
6. Heather A. Hoke
7. Warren A. Whyte
8. Stuart H. Orkin

In Obstetrics and Gynecology

1. A. Moffett-King

In Pediatrics, Perinatology and Child Health

1. A. Moffett-King

Citations in the corpus

• Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. (2011, background): “It should be noted that there are differences between mouse and human placentae, such as the greater role of yolk sac placentation in the mouse and the anatomy in the labyrint”
• Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. (2002, background): “While some of the gross anatomy and physiology of the mouse and human placenta are different, they share considerable cellular and molecular features (Hemberger and Cross, 2001; Rossant and Cross, 2001).”
• Enhancer decommissioning by LSD1 during embryonic stem cell differentiation (2012, background): “Further analysis of ESCs that were forced to differentiate in the absence of LSD1 activity confirmed that these cells failed to make a complete transition from the ESC gene expression program; although key genes of the trophectoderm gene expression program were activated, including Cdx2 and Esx1 ”
• Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. (2005, positive): “For our functional analysis, we chose eight transcription factor genes as TE markers, including Cdx2, Eomeso, Hand1, Esx1, Dlx3, Psx1, Ets2, and Errb; this selection was based on the expression of these genes during TE differentiation and their mutant phenotypes (Rossant and Cross, 2001).”
• The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (2007, background): “Given the primordial role of fibroblast growth factor 4 (FGF4) in promoting the proliferation of trophectoderm cells (Rossant and Cross, 2001) and the importance of ERK1/ERK2 MAP kinases in transducing signals from growth factor receptors, it has been suggested that ERK2 functions downstream of FGF…”
• The placenta is a niche for hematopoietic stem cells. (2004, background): “…which consists of endothelial cell-lined fetal e acapillaries and trophoblast-lined maternal blood sinuses, and permits the exchange of gases and nutri- e hents between maternal and fetal circulatory systems (Adamson et al., 2002; Downs, 2002; Downs and Gard- w sner, 1995; Rossant and Cross, 2001).”
• Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. (2004, background): “of nutrients, wastes, and gasses takes place (58).”
• Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst (2005, background): “Further differentiation of the trophoblast lineage generates the labyrinth, spongiotrophoblast and glycogen cells of the mature chorioallantoic placenta (Rossant and Cross, 2001).”
• The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. (2004, result): “This is in contrast to many other KO situations with placental defects, where there is a clear size reduction of different layers and a compromised function of trophoblast cells (for review, see Rossant and Cross 2001).”
• Multipotent cell lineages in early mouse development depend on SOX2 function. (2003, background): “Conversely, the mural trophectoderm, which is not in contact with the ICM, ceases to divide and terminally differentiates into primary trophoblast giant cells (Rossant and Cross 2001).”
• Natural killer cells and pregnancy (2002, background): “Mice are the obvious animal model, but although humans and mice have the same HAEMOCHORIAL type of placentation and have many features in common, there are also substantial differences that are often ignore”