Programmed anuclear cell death delimits platelet life span.
By K. Mason, M. Carpinelli, J. Fletcher, Janelle E. Collinge, Adrienne A. Hilton, S. Ellis, Priscilla N. Kelly, P. Ekert, D. Metcalf, A. Roberts and 2 more. Cell, 2007
1,027 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/cb5895169d9a0565823e8ff9b0f1dc4f6ef6e5e1
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In Molecular Biology
- A. Strasser
- P. Czabotar
- G. Lessene
- R. Youle
- P. Colman
- L. Cañedo-Dorantes
- Mara Cañedo-Ayala
- Stephen W. Fesik
In Physiology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. (2008, background): “Recent reports have also described hypomorphic mutations in Bcl-x , which lead to thrombocytopenia in mice similar to that observed with ABT-737 treatment (45).”
- BCL-2 family antagonists for cancer therapy (2008, background): “Furthermore, BCL-X L is essential for regulating platelet surviva”
- Skin Acute Wound Healing: A Comprehensive Review (2019, background): “progressive degradation of the antiapoptotic protein Bcl-xL determines the lifespan of platelets in the blood, and at the end of their life, they are removed from the circulation in the liver and spleen [25, 26].”
- Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. (2012, background): “Pharmacologic inhibition of BCL-xL in mice 20 or dogs(23) causes an acute, dose-proportional reduction in platelet count within 1 to 2 days via induction of apoptosis(24) and subsequent clearance of platelets from the circulation.(20) Megakaryocytes and reticulated platelets are less susceptible, an”
- The BCL-2 protein family: opposing activities that mediate cell death (2008, background): “, although they do exhibit mild platelet hypertrophy owing to a requirement for BAK to mediate the turnover of these anuclear cellular fragment”