In vivo molecular target assessment of matrix metalloproteinase inhibition

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Gelatinase-mediated migration and invasion of cancer cells. (2005, methodology): “The MMP inhibitors coupled to imaging agents could be used to detect small tumors due to their tumor-targeting properties (Bremer et al., 2001; Li and Anderson, 2003; Medina et al., 2001).”
Peptide-based Probes for Targeted Molecular Imaging (2010, background): “A widely-reported activatable probe represents the first biocompatible polymer-associated imaging probe for matrix metalloproteinase (MMP) imaging in vivo (102).”
Matrix metalloproteinases and tumor metastasis (2006, methodology): “In vivo assessment of MMP inhibition has been designed to sense MMP activity in intact tumors by direct imaging of live animals injected with the biocompatible fluorogenic MMP substrates serving as activatable reporter probes [112].”
Molecular imaging in living subjects: seeing fundamental biological processes in a new light. (2003, background): “3; Bremer et al. 2001a,b).”
Near-infrared optical imaging of proteases in cancer. (2003, background): “The time for imaging after probe administration may be as short as 2 h, depending upon the location of the enzyme being imaged (32); optimal timing after injection depends as well upon the disease imaged (33, 34).”