Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

By C. Venegas, Sathish Kumar, B. S. Franklin, T. Dierkes, Rebecca Brinkschulte, Darío Tejera, A. Vieira-Saecker, S. Schwartz, Francesco Santarelli, Markus P Kummer and 9 more. Nature, 2017

874 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/cb17ef0ab08a09442fa73b451fad4635f8d4ab3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Long
2. Kate Schroder
3. M. Butler
4. Joachim L. Schultze
5. E. Wohleb
6. D. Holtzman
7. P. Oliver
8. Luke A. O'Neill

In Neurology

1. S. Woodburn
2. J. Long
3. Chao Gao
4. Shengdi Chen
5. Yuyan Tan
6. Jingwen Jiang
7. Joachim L. Schultze
8. J. Bollinger

In Physiology

1. J. Long
2. Kate Schroder
3. Dominic S A Simpson
4. M. Butler
5. D. Holtzman
6. P. Oliver
7. Luke A. O'Neill
8. Berislav Zlokovic

Citations in the corpus

• Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice (2018, positive): “Collectively, these findings provide insight into the neuroinflammatory pathology of PD, with potential therapeutic relevance given the emerging paradigm whereby extracellular ASC propagates inflammatory responses in vivo and can increase the formation of amyloid- aggregates by acting as a cross-se”
• The semantics of microglia activation: neuroinflammation, homeostasis, and stress (2021, result): “In contrast, other work suggests that microglia release Aβ and tau “seeds”, which exacerbate AD progression [75, 76].”
• Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019, positive): “This can be reversed by genetic deletion of ASC or use of an anti-ASC neutralizing antibody (Venegas et al., 2017).”
• ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020, background): “ROS from NOX4 also contribute to activation of the NLRP3 inflammasome, a driver of both amyloid-β [156] and tau [23] pathology.”
• Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “After being released from microglia, ASC specks bind to and promote the cross-seeding of Aβ, leading to amyloid seeding and spreading of amyloid pathology.(153) To examine whether microglia contribute to Aβ propagation, d’Errico P et al.”