The Jak-STAT pathway.

By Kazuroni Imada, W. Leonard. Molecular Immunology, 2000

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Mechanisms and functional significance of tumour-induced dendritic-cell defects (2004, background): “Although JAK activation might contribute to the specificity of the receptors, the JAKs are not absolute determinants of the specificity of cytokine-mediated signalling, because different cytokines can activate the same JAKs (reviewed in Ref”
Cytokines, prostaglandins and parturition--a review. (2003, background): “The receptors for several significant pro- and anti-inflammatory cytokines bind to members of the JAK family of tyrosine kinases and activate downstream STAT signalling (Imada and Leonard, 2000).”
STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “STAT 1 and 3 with this altered serine have a transcriptional capacity reduced by 20% (Imada and Leonard, 2000).”
The protein tyrosine kinase family of the human genome (2000, background): “…et al., 1998; Pendergast, 1996 FRK Lee, 1998; Vasioukhin and Tyner, 1997; Kohmura et al., 1994; Lee et al., 1994 JAK Danial and Rothman, 2000; Imada and Leonard, 2000; Aringer et al., 1999; Leonard and O'Shea, 1998 SRC Abram and Courtneidge, 2000; Schlessinger, 2000; Schwartzberg, 1998;…”