Palmitoylation: policing protein stability and traffic

By M. Linder, R. Deschenes. Nature reviews. Molecular cell biology, 2007

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Tetraspanins: push and pull in suppressing and promoting metastasis (2009, neutral): “Taking into account the reversibility of palmitoylatio”
Activation of STING requires palmitoylation at the Golgi (2016, positive): “Protein palmitoylation has been implicated in the clustering of a number of proteins 30 such as H-ras and Fas into lipid rafts (speciﬁc membrane domains enriched in cholesterol and sphingomyelin (SM)).”
CSS-Palm 2.0: an updated software for palmitoylation sites prediction. (2008, background): “Palmitoylation will enhance surface hydrophobicity and membrane affinity of protein substrates, and plays important roles in modulating proteins’ trafficking (Draper et al., 2007; Linder and Deschenes, 2007), stability (Linder and Deschenes, 2007), sorting (Greaves and Chamberlain, 2007) and so on.”
Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications (2017, background): “Reversibility makes this modification an interesting mechanism for the regulation of protein activity and stability, protein-protein interactions, and shuttling of proteins between subcellular compartments when there are modifications of signal transduction (Greaves and Chamberlain, 2007; Linder and”