Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

By Mi‐Hye Lee, K. Lu, S. Hazard, Hongwei Yu, S. Shulenin, H. Hidaka, H. Kojima, R. Allikmets, N. Sakuma, R. Pegoraro and 4 more. Nature Genetics, 2001

709 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/ca8fb3eaaed5be1b17f94683a10be93163af8a78

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Helen H. Hobbs
2. Jonathan C. Cohen
3. Xiaochun Li
4. Xiaofeng Qi
5. C. Klaassen
6. Jay D. Horton
7. Lauren M. Aleksunes

In Oncology

1. C. Klaassen
2. Jay D. Horton
3. Lauren M. Aleksunes

In Surgery

1. Jonathan C. Cohen
2. Jay D. Horton
3. Helen H. Hobbs
4. J. Goldstein
5. Michael S. Brown

Citations in the corpus

• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “This rare, autosomal recessive disorder results from mutations in ABCG5 and ABCG8 that consequently impair the biliary excretion of sterols (Berge et al., 2000; Lee et al., 2001b; Lu et al., 2001).”
• The human ATP-binding cassette (ABC) transporter superfamily. (2001, neutral): “Recently, two half-transporter genes, ABCG5 and ABCG8 were characterized (Berge et al. 2000; Lee et al. 2001), located head-to-head on the human chromosome 2p15-p16, and regulated by the same promoter.”
• Molecular basis of cholesterol efflux via ABCG subfamily transporters (2021, background): “, cholesterol) as well as premature atherosclerosis (6, 7).”
• Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. (2002, positive): “Recently, a critical component of the transport machinery for dietary sterols was revealed by the finding that mutations in the genes encoding the ATPbinding cassette (ABC) half-transporters ABCG5 and ABCG8 cause sitosterolemia, a rare autosomal recessive disorder of sterol metabolism (4, 5).”
• The human ATP-binding cassette (ABC) transporter superfamily. (2001, neutral): “ABCG5 and G8 (49, 50), have been implicated in the genesis”