Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.

By Liqing Yu, J. Li-Hawkins, R. Hammer, K. Berge, Jay D. Horton, Jonathan C. Cohen, Helen H. Hobbs. Journal of Clinical Investigation, 2002

732 citations recorded by the source corpus.

Subfields: Biochemistry, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/ca43a7e87d73f21dd903c748c41944adde9c35c1

How researchers see this paper

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In Biochemistry

1. P. Tontonoz

In Oncology

1. P. Tontonoz
2. D. Mangelsdorf

In Surgery

1. P. Tontonoz
2. D. Mangelsdorf
3. S. Bensinger

Citations in the corpus

• Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. (2004, unknown): “The decreases in the regulatory enzymes of both the classic and alternative pathways of bile acid synthesis as well as the decrease in ABCG5 and ABCG8 induced by LPS and cytokines suggest that during infection the body’s need to conserve cholesterol is so essential that all of these pathways are dow”
• Liver X receptor signaling pathways in cardiovascular disease. (2003, background): “Similar changes have been observed in transgenic mice overexpressing the human ABCG5 and ABCG8 genes (36).”