Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.
By M. Sato, H. Suemori, N. Hata, M. Asagiri, K. Ogasawara, K. Nakao, T. Nakaya, M. Katsuki, S. Noguchi, N. Tanaka and 1 more. Immunity, 2000
794 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/ca38cdc11b3fee9b3dcb76c77593b9a80e456776
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Citations in the corpus
- Regulation and Function of IKK and IKK-Related Kinases (2006, background): “Small amounts of initially produced IFN-I up-regulate the expression of secondary IFN-I genes and IFN-I–responsive genes, including IRF7, by virtue of a feed-forward loop, thereby leading to a robust and measurable IFN-I response (172, 175).”
- RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “Analysis of KO mice of these two genes clearly showed their essential role in the activation of antiviral immunity (31, 32).”
- Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA (2014, background): “…caspase-3, caspase-7, Apaf-1, IFNAR1, IRF-3, IRF-7, MAVS, and cGAS (Mb21d1 / ) -deficient mice have been reported previously (Honda et al., 2005; Kuida et al., 1996, 1998; Lakhani et al., 2006; Li et al., 2013; Müller et al., 1994; Sato et al., 2000; Sun et al., 2006; Yoshida et al., 1998).”
- A Mouse Model of Zika Virus Pathogenesis (2016, unknown): “A and B: n = 16 (Ifnar1−/−), 5 (Irf3−/− Irf5−/− Irf7−/− TKO, Mavs−/−, WT), 9 (Irf3−/−).”
- Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB (2009, methodology): “IRF-3–deficient mice (26) were kindly donated by Dr.”
- Peroxisomes are signaling platforms for antiviral innate immunity (2010, background): “While we found that IRF3 plays a role in ISG expression, this factor is also involved in the regulation of IFN expression (Sato et al., 2000) and may therefore be considered a more general regulator of antiviral gene expression.”
- Immunobiology and pathogenesis of viral hepatitis. (2006, background): “Furthermore, reports that NDVinduced IFN-α/β mRNA expression is profoundly reduced in IRF-3-deficient cells (154) suggest that IRF-3 is required for IFN induction following viral infection.”
- Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, unknown): “IRF3 is essential for the antiviral ISD response (Stetson and Medzhitov, 2006a), we examined the contribution of the ISDIRF3 pathway by breeding Trex1-deficient mice to IRF3-deficient mice (Sato et al., 2000).”
- Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I (2005, background): “these, IRF3 is essential for IFN production (21).”