Pyroptosis: mechanisms and diseases

By Pian Yu, Xu Zhang, Nian Liu, Ling Tang, C. Peng, Xiang Chen. Signal Transduction and Targeted Therapy, 2021

1,994 citations recorded by the source corpus.

Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.

Subfields: Molecular Biology, Nephrology, Oncology

View Paper: https://www.semanticscholar.org/paper/eba11979f31e71c89daf037d5d6be03eb7d7c34b

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In Molecular Biology

1. D. Tang
2. Xin Chen
3. D. Klionsky
4. Guido Kroemer
5. R. Kang
6. N. Mizushima
7. Beth Levine
8. Ralph A. Nixon

In Oncology

1. Xin Chen
2. D. Klionsky
3. D. Tang

Citations in the corpus

• Copper metabolism in cell death and autophagy (2023, background): “The N-terminal domain of GSDMD then binds to the cell membrane, forming oligopores, which further leads to water inflow, dissolution, and cell death [120,121].”
• Role of pyroptosis in inflammation and cancer (2022, methodology): “Simultaneously, ELISAs are used to determine the release amount of cytokines such as IL-1β and IL-18 from cells into the culture medium, and western blotting is performed to determine caspase-1 and gasdermin D cleavage [26, 27].”