The PAR-aPKC system: lessons in polarity
By A. Suzuki, S. Ohno. Journal of Cell Science, 2006
741 citations recorded by the source corpus.
Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase, whereas PAR-3 is a PDZ-domain-containing scaffold protein. Work over the past decade has shown that they are part of an evolutionarily conserved PAR-aPKC system involved in cell polarity in various biological contexts. Recent progress has illustrated the common principle that the PAR-aPKC system is the molecular machinery that converts initial polarity cues in the establishment of complementary membrane domains along the polarity axis. In most cases, this is achieved by mutually antagonistic interactions between the aPKC-PAR-3-PAR-6 complex and PAR-1 or PAR2 located opposite. However, accumulating evidence has also revealed that mechanisms by which the asymmetrically localized components of the PAR-aPKC system are linked with other cellular machinery for developing polarity are divergent depending on the cell type.
Subfields: Aging, Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/c96294c1074bd9367e4e80e9f62083a208a59929
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In Aging
In Molecular Biology
- A. Cano
- G. Moreno-Bueno
- F. Portillo
- Juergen A. Knoblich
- M. Nieto
- R. Weinberg
- Thomas Brabletz
- Simone Brabletz
In Plant Science
Citations in the corpus
- Transcriptional regulation of cell polarity in EMT and cancer (2008, background): “…of cell polarity is the result of mutually antagonistic interactions between the PAR, CRB and SCRIB complexes, where the Par6/Par3/aPKC complex has a pivotal function and Rac1/Cdc42 GTPases activation triggers the process (reviewed by Suzuki and Ohno, 2006; Etienne-Manneville, 2008; Figure 1).”
- Mechanisms of asymmetric stem cell division. (2008, background): “Before mitosis, the proteins Par-3, Par-6, atypical PKC (aPKC), Inscuteable, Pins, Gai, and Mud (see below for their individual functions) accumulate on the apical side of the cell cortex (Betschinger and Knoblich, 2004; Suzuki and Ohno, 2006; Goldstein and Macara, 2007).”