Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning.

By Zhi-Qing Zhao, J. Corvera, Michael E. Halkos, Faraz Kerendi, Ningping Wang, R. Guyton, J. Vinten-johansen. American Journal of Physiology. Heart and Circulatory Physiology, 2003

2,224 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Emergency Medicine, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c8e2ba8254c15f1ca42c3d86fc19d89d14f55573

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. D. Yellon
2. D. Hausenloy
3. G. Heusch

In Emergency Medicine

1. D. Yellon
2. D. Hausenloy
3. E. Murphy
4. C. Steenbergen

In Pathology and Forensic Medicine

1. D. Yellon
2. D. Hausenloy
3. E. Murphy
4. C. Steenbergen
5. M. Mocanu
6. A. Tsang
7. G. Heusch
8. S. Cadenas

Citations in the corpus

• Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. (2004, background): “[9,10] in the canine model, and suggest that at least the later phase of ROS generation is attenuated by postconditioning.”
• Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. (2008, background): “In 2003 Zhao et al. reported that intermittent reperfusion, after ischemia, can also reduce infarct size (287).”
• Myocardial ischemia-reperfusion injury: a neglected therapeutic target. (2013, positive): “In contrast to unimpeded reperfusion, IPost is intermittent reperfusion of the acute ischemic myocardium, which has been reported to prevent myocardial reperfusion injury and reduce MI size by 40%–50% (61).”
• Postconditioning: A Form of “Modified Reperfusion” Protects the Myocardium by Activating the Phosphatidylinositol 3-Kinase–Akt Pathway (2004, methodology): “02% dimethyl sulfoxide (DMSO) vehicle (n 4) for the first 15 minutes of reperfusion; (2) IPC (n 11), comprising 2 cycles of 5 minutes of global ischemia followed by 10 minutes of reperfusion before the index ischemia; (3) Postcond (n 10), comprising 6 cycles of 10 seconds of reperfusion followed by ”