Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold.

By Wan-Ju Li, R. Tuli, Xiaoxue Huang, P. Laquerriere, Rocky S. Tuan. Biomaterials, 2005

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Three-Dimensional Cell Culture Matrices: State of the Art (2008, neutral): “Electrospinning techniques can also reduce fiber diameter to the nano-scale.(44) The last approach is postfabrication surface treatment or surface coating (Fig.”
Bone tissue engineering: A review in bone biomimetics and drug delivery strategies (2009, background): “Both in vitro and in vivo studies have demonstrated that osteoprogenitor cells differentiate, proliferate, and adhere in synthetic nanofibrous matrices.(211,212)”
Electrospinning of Polymeric Nanofibers for Tissue Engineering Applications: A Review (2006, neutral): “79 Marrow stromal cells seeded on electrospun PCL and in the presence of transforming growth factor-(cid:4) (TGF-(cid:4) ) differentiated into a chondrocytic phenotype at levels comparable to traditional pellet cultures.”
The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. (2008, methodology): “MSCs were chosen for this application as they can assume a number of different phenotypes [30,31], and have been used in various attempts to engineer fibrous tissues with electrospun scaffolds [16,32].”