Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging

By Mark D'Esposito, Leon Y. Deouell, Adam Gazzaley. Nature Reviews Neuroscience, 2003

914 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/c8ac2e2b4232dac40781c7cb01f1749077c46158

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In Cognitive Neuroscience

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Age-related changes in modular organization of human brain functional networks (2009, neutral): “Likewise, there is some prior evidence for age-related differences in the form of the hemodynamic response function mediating the BOLD response in fMRI (D'Esposito et al. 2003) and this could conceivably have affected our results.”
Disruption of large-scale brain systems in advanced aging. (2007, neutral): “A number of control analyses were performed to address concerns that our observed effects were simply due to systematic differences in the fMRI signal (Buckner et al., 2000; D’Esposito et al., 2003).”
Multimodal population brain imaging in the UK Biobank prospective epidemiological study (2016, neutral): “For example, abnormal heart rate or blood pressure could alter the fMRI signal through disrupted cerebral auto-regulation (independent of any changes to neural activity)40, but cardiovascular pathology could also be related to neurological pathology.”
Glial and neuronal control of brain blood flow (2010, neutral): “Such changes in neurovascular coupling may make it hard to interpret BOLD fMRI signals from older subject”
A Baseline for the Multivariate Comparison of Resting-State Networks (2011, background): “, baseline levels of blood flow, vascular compliance, cardiac and respiratory rhythms) that are known to change with age and therefore preclude a full interpretation of age-related findings (D’Esposito et al., 2003; Birn et al., 2006, 2008; Ances et al., 2009).”
Using human brain lesions to infer function: a relic from a past era in the fMRI age? (2004, neutral): “For example, current techniques are much more sensitive in younger people than in older peopl”
Handbook of Functional MRI Data Analysis: Index (2011, background): “And D’Esposito et al. (2003) reviewed a number of studies that compared the BOLD response in healthy young and eldery subjects and found, while the shape of the HRF was simlar between the groups, elderly had reduced signal-to-noise ratios in the response magnitudes.”
Resting-state FMRI confounds and cleanup (2013, neutral): “Changes in vascular structure and integrity with age and disease causemany changes in neurovascular coupling: atherosclerosis, increased tortuosity, changes in collateral circulation after recanalization of occluded cerebral vessels, reduction in resting CBF, changes in vascular reactivity, lowered ”