Using human brain lesions to infer function: a relic from a past era in the fMRI age?

By C. Rorden, Hans-Otto Karnath. Nature Reviews Neuroscience, 2004

685 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/5fad4dda852c56b0cda4594dfa6e5825e789094d

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Citations in the corpus

Insights into the neural basis of response inhibition from cognitive and clinical neuroscience. (2009, positive): “, 2007) are selectively crucial for response inhibition? One possibility is that the failure to observe a critical role of IFG or SMA/preSMA reflects functional reorganization of intact areas, which then compensate for damage to centres that would be crucial in the healthy brain (Rorden and Karnath,”
Improving Lesion-Symptom Mapping (2007, methodology): “Nevertheless, lesion mapping continues to offer a unique and powerful tool for understanding of brain function, complementing recent methods that measure brain activation in healthy adults (Fellows et al., 2005; Rorden & Karnath, 2004 ).,FDR has also been previously employed both in voxelwise analy”
Executive “Brake Failure” following Deactivation of Human Frontal Lobe (2006, background): “However , because such studies rely on patients with permanent brain lesions, definitive conclusions regarding the role of specific areas may be limited by the brain's capacity to functionally reorganize following injury (Rorden & Karnath, 2004; Wall, Xu, & Wang, 2002).”
A distributed brain network predicts general intelligence from resting-state human neuroimaging data (2018, background): “Lesion studies in humans are an opportunity to establish causation [53], although they come with their own set of limitations [54].”
Functions of the left superior frontal gyrus in humans: a lesion study. (2006, background): “Therefore, lesion studies in humans are particularly useful to complement experimental studies in animals and functional imaging studies (Rorden and Karnath, 2004), although, in this particular study, some limitations should be pointed out: (i) lesions tend not to be conveniently localized in…”
Power in Voxel-based Lesion-Symptom Mapping (2007, methodology): “Rorden and Karnath (2004) review a number of general limitations of lesion analysis that are not specific to VLSM, including the assumption of modularity, variability in functional organization, the nonrandom spatial distribution of lesions, and the potential disconnect between structural and…”
Dorsolateral prefrontal contributions to human working memory. (2013, background): “…the methodological limitations of earlier non-human primate and functional neuroimaging studies by investigating the anatomical localization of working memory functions in the human brain (Rorden and Karnath, 2004) and evaluating the necessity of the dlPFC for specific components of working memory.”
Executive Brake Failure following Deactivation of Human Frontal Lobe (2006, background): “However, because such studies rely on patients with permanent brain lesions, definitive conclusions regarding the role of specific areas may be limited by the brain’s capacity to functionally reorganize following injury ( Rorden & Karnath, 2004; Wall, Xu, & Wang, 2002).”
Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making (2008, background): “Lesion designs (or other interventional techniques like transcranial magnetic stimulation) are a crucial methodology in order to demonstrate the necessary involvement of a brain region in a particular process (Rorden and Karnath, 2004).”