Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

By S. Man, Rajendra Karki, T. Kanneganti. Immunological Reviews, 2017

1,419 citations recorded by the source corpus.

Cell death is a fundamental biological phenomenon that is essential for the survival and development of an organism. Emerging evidence also indicates that cell death contributes to immune defense against infectious diseases. Pyroptosis is a form of inflammatory programmed cell death pathway activated by human and mouse caspase‐1, human caspase‐4 and caspase‐5, or mouse caspase‐11. These inflammatory caspases are used by the host to control bacterial, viral, fungal, or protozoan pathogens. Pyroptosis requires cleavage and activation of the pore‐forming effector protein gasdermin D by inflammatory caspases. Physical rupture of the cell causes release of the pro‐inflammatory cytokines IL‐1β and IL‐18, alarmins and endogenous danger‐associated molecular patterns, signifying the inflammatory potential of pyroptosis. Here, we describe the central role of inflammatory caspases and pyroptosis in mediating immunity to infection and clearance of pathogens.

Subfields: Hematology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/c8a68a56d3faf02e22d962b297b4ea54f18cc540

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In Hematology

1. T. Kanneganti

In Molecular Biology

1. T. Kanneganti
2. R. Malireddi
3. S. Kesavardhana
4. Jingjin Ding
5. Kun Wang
6. F. Shao
7. A. Grebe
8. E. Latz

In Surgery

1. R. Malireddi
2. S. Kesavardhana
3. T. Kanneganti

Citations in the corpus

• Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. (2020, background): “Excessive pyroptosis causes various inflammatory diseases like sepsis (Man et al., 2017; Manthiram et al., 2017; Swanson et al., 2019).”
• Pattern Recognition Receptors and the Host Cell Death Molecular Machinery (2018, background): “Pyroptosis Pyroptosis is a necrotic form of regulated cell death distinct from necroptosis, mainly due to the requirement of inflammatory caspase-1 and/or caspase-11 (murine caspase-11 corresponds to caspases-4 and -5 in humans) [(136); Figure 3].”
• Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options (2022, background): “Pyroptosis is characterized by the loss of membrane integrity, cell swelling and rupture, followed by the release of pro-inflammatory intracellular contents [37, 38].”
• Role of pyroptosis in inflammation and cancer (2022, background): “Pyroptosis is an important natural immune response that specifically antagonizes infection and endogenous danger signals [1, 28, 29].”
• NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. (2018, background): “For example, NLRP1 detects anthrax lethal toxin in mice, NLRC4 is activated by different NAIPs (NOD-like receptor family apoptosis inhibitory proteins) which recognize flagellin or components of the bacterial type III secretion system, AIM2 binds cytosolic double-stranded DNA and pyrin is activated ”
• Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis (2020, background): “Wang J, Sahoo M, Lantier L,Warawa J, Cordero H, et al. 2018 Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.”