Matrix metalloproteinases: a tail of a frog that became a prince

By C. Brinckerhoff, L. Matrisian. Nature reviews. Molecular cell biology, 2002

1,149 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/c8a1f615e3b61b884b6893b713f37e8cc46b6d94

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Zena Werb
2. C. López‐Otín
3. C. Malemud
4. Andrew J. Ewald
5. Wen-Sheng Wu
6. Andrea Page-McCaw
7. D. Tuveson
8. T. Jacks

In Hematology

1. Zena Werb
2. C. López‐Otín
3. C. Malemud
4. Wen-Sheng Wu
5. T. Jacks
6. Valerie M. Weaver
7. Pengfei Lu

In Oncology

1. C. López‐Otín
2. Zena Werb
3. Andrew J. Ewald
4. D. Tuveson
5. C. Malemud
6. Wen-Sheng Wu
7. T. Jacks
8. Andrea Page-McCaw

Citations in the corpus

• The signaling mechanism of ROS in tumor progression (2007, background): “tasis-related genes such as integrins and MMPs [23–25].”
• EMT and tumor metastasis (2015, background): “MMPs are capable of cleaving cell-surface proteins as well as degrading components of the extracellular matrix, allowing migratory cells to invade neighboring tissues and break through the basement membrane [49].”
• Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP (2004, background): “Similarly, although recent reports posit a preeminent role for MMP-2 in degradative events after its TIMP-2–dependent activation by MT1-MMP (Brinckerhoff and Matrisian, 2002; Seiki et al., 2003), MMP-2 / as well as TIMP-2 / fibroblasts also mount normal collagenolytic responses, effectively eliminat”
• Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. (2003, background): “Finally, we investigated the expression of matrix metalloproteinase-7 (MMP-7), a member of the family of zinc-dependent extracellular proteases (Brinckerhoff and Matrisian, 2002).”
• Luteolin, a flavonoid with potential for cancer prevention and therapy. (2008, background): “This process, namely metastasis, contributes to over 90% of human cancer mortality [127].”
• Matrix metalloproteinases (MMPs) in health and disease: an overview. (2006, background): “MMPs are up-regulated in arthritis by elevated synovial fluid levels of IL-1beta and TNF-alpha where MMP-1 (collagenase-1) and MMP-13 (collagenase-3) activity predominate (37).”
• Matrix MetalloProteinases (MMPs) andTissue Inhibitors of MetalloProteinases (TIMPs): positive and negative regulators intumor cell adhesion (2010, neutral): “MMPs belong to a family of zinc-dependent endopeptidases intrinsically responsible for the degradation of a vast number of protein targets by cleavage of internal peptide bonds[55,56].”
• Matrix metalloproteinases and the regulation of tissue remodelling (2007, background): “MMP2 and MMP9 have three fibronectin type II repeats in their catalytic domains (2).”