Mechanisms of biofilm resistance to antimicrobial agents.

By T. Mah, G. O’Toole. Trends in Microbiology, 2001

3,939 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/c88cac0941672f1ff9e21f32dc0cb96007ed7fe0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Microbiology

1. S. Gellatly
2. D. Ren
3. A. A. Bahar
4. M. Otto
5. J. Kaplan
6. F. Götz
7. Robert E. W. Hancock
8. Frederick M. Ausubel

In Molecular Biology

1. M. Otto
2. J. Kaplan
3. S. Ha
4. I. Jahid
5. S. Gellatly
6. D. Wozniak
7. G. O’Toole
8. T. Mah

In Organic Chemistry

1. F. Götz
2. M. Otto
3. J. Kaplan
4. Robert E. W. Hancock
5. S. Ha
6. I. Jahid

Citations in the corpus

• Antimicrobial Peptides (2013, background): “In addition to the protection by the extracellular matrix [201], biofilm associated antibiotic resistance is also attributed to the slow growth of biofilm cells [202].”
• Biofilm bacteria: formation and comparative susceptibility to antibiotics. (2002, background): “In human medicine it has been estimated that 65% of nosocomial infections are biofilm associated, costing the health care system billions of dollars (1,3,15).”
• A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance (2003, background): “and the reported ability of biofilms to develop broad resistance to antimicrobial agent”
• Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. (2013, background): “…to an upregulation of the general stress response alternative sigma factor RpoS; all of these factors might lead to increased antibiotic resistance (Mah & O’Toole, 2001), which has also been proposed to be due to adaptive changes in gene expression, slow penetration, QS, and higher extracellular…”
• Staphylococcus and biofilms (2002, background): “Thus, the reason for the increased antibiotic resistance of biofilm-imbedded staphylococci remains unknown (Mah and O’Toole, 2001).”
• Major foodborne pathogens in fish and fish products: a review (2015, background): “Interestingly, it has been observed that the resistance of bacterial cells to antimicrobials in biofilms is significantly increased compared to what is normally seen with the same bacterial cells when not in biofilms (Mah and O’Toole 2001; Gilbert et al. 2002).”
• Genes involved in matrix formation in Pseudomonas aeruginosa PA14 biofilms (2003, background): “Biofilm formation appears to be a widespread attribute of bacteria and may allow increased survival ability under stressful conditions such as low nutrients or antimicrobial treatments (Costerton et al ., 1995; Mah and O’Toole, 2001).”