Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression

By J. Zeitzer, D. Dijk, R. Kronauer, E. Brown, Charles A. Czeisler. Journal of Physiology, 2000

1,217 citations recorded by the source corpus.

Subfields: Biophysics, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/c80dc021d30aa4ae0b9528d92f41091aa9dc4f67

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In Endocrine and Autonomic Systems

Citations in the corpus

Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness (2014, background): “In humans, exposure to light in the evening and early part of the night, even at low intensity, suppresses the release of the sleep-facilitating hormone melatonin (3–5) and shifts the circadian clock to a later time (3, 6), both of which make it more difficult to fall asleep at night.”
Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. (2000, background): “In the remaining 21 subjects, light was calculated to have been centered on average 1.969 0.95 (S.D.) h before the fitted maximum of the plasma melatonin rhythm [40] .”
Effects of playing a computer game using a bright display on presleep physiological variables, sleep latency, slow wave sleep and REM sleep (2005, background): “More recent studies have shown that exposure to light of relatively low intensity can aﬀect human circadian rhythm (Boivin et al. , 1996; Zeitzer et al. , 2000) and that performing an exciting video display terminal (VDT) task using a bright display suppressed nocturnal salivary melatonin secretion…”
A Phase Response Curve to Single Bright Light Pulses in Human Subjects (2003, methodology): “…to exhibit a normal circadian rhythm in core body temperature with a minimum fitted amplitude of 0.14 °C during the first CR (see below) before they were qualified to continue the study (Czeisler et al. 1989; Duffy et al. 1996; Jewett et al. 1997; Shanahan et al. 1999; Zeitzer et al. 2000).”
Light Pollution, Circadian Photoreception, and Melatonin in Vertebrates (2019, methodology): “…= 23 mean age 27.8 ± 8.91 (18–44 years) 3 lx 106 lx 9100 lx 6–5-h pulse Cool light Dim light Laboratory MEL in plasma 3 lx: −11% N/A 106 lx: −88% N/A 9100 lx: −98% N/A (Zeitzer et al. 2000) [134] Sustainability 2019, 11, 6400 26 of 51 Sustainability 2019, 11, x FOR PEER REVIEW 24 of 57 4.2.6.”
Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption (2017, background): “The effect of light depends also on its intensity and duration [16,17], aswell as its spectral properties, since intrinsically photosensitive retinal ganglion cells (ipRGCs) in the eye contain melanopsin, which is a photoreceptor that relays the light versus dark signaling signal in the retina.”
An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans (2001, background): “…et al. 2000), suppression of pineal melatonin production (Lewy et al. 1980; Bojkowski et al. 1987; McIntyre et al. 1989; Brainard et al. 1997; Zeitzer et al. 2000), elevation of core body temperature (Badia et al. 1991), pupil constriction, reduced slow eye movements and enhanced alertness…”
Sleep, circadian rhythms, and delayed phase in adolescence. (2007, background): “[26] Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C.”
Sleep patterns and predictors of disturbed sleep in a large population of college students. (2010, methodology): “The Subjective Units of Distress Scale is used to assess an individual’s baseline level of stress [26].”
Causes and consequences of sleepiness among college students (2014, neutral): “Melatonin is suppressed by light, and light sources as low 200–300 lux (room lights) can cause suppression.(53) The amount of light from technologic devices is variable; for example, a tablet computer generated 50 lux suppressed melatonin in a cohort of college students after 2 hours of use.”
Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle (2013, background): “Average exposure of participants to light intensities during waking hours for light levels with characterized circadian properties in accordancewith intensity and phase response curves to light [13, 14, 16] are provided.”