A Phase Response Curve to Single Bright Light Pulses in Human Subjects

By S. B. Khalsa, Megan E. Jewett, C. Cajochen, Charles A. Czeisler. Journal of Physiology, 2003

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Sleep, circadian rhythms, and delayed phase in adolescence. (2007, background): “1 shows a PRC to light for adult humans, constructed by Khalsa and colleagues (2003) [34].”
Sleep patterns and predictors of disturbed sleep in a large population of college students. (2010, background): “(2003) [34].”
High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. (2005, background): “Monochromatic light exposure (2 h) was scheduled at a circadian phase at which polychromatic, white light exposure induces robust phase delays (1, 2, 23) and alerting effects (24).”
Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness (2014, background): “In humans, exposure to light in the evening and early part of the night, even at low intensity, suppresses the release of the sleep-facilitating hormone melatonin (3–5) and shifts the circadian clock to a later time (3, 6), both of which make it more difficult to fall asleep at night.”
Physiology of circadian entrainment. (2010, background): “The PRC, its shape and amplitude, is an intrinsic property of the circadian oscillator and is characteristic for each species, including humans (243, 321), that also respond to relatively low intensities of light (503).”