An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans

By K. Thapan, J. Arendt, D. Skene. Journal of Physiology, 2001

1,377 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e7a8ba7cd437864251429b4b190ea9b4ff3a2523

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Citations in the corpus

Non-image forming effects of illuminance and correlated color temperature of office light on alertness, mood, and performance across cognitive domains (2019, background): “In addition, the peak sensitivity of the photopigment mela-nopsin in ipRGCs to light is in the blue part of the spectrum (around 460 – 480 nm) [1,4,49,50].”
High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. (2005, result): “Our data are in good agreement with recent findings that the human circadian pacemaker is highly sensitive to short wavelength light (13, 30), as indexed by action spectra for human melatonin suppression and assessment of human circadian phase resetting (5, 6).”
Influence of blue-enriched classroom lighting on students׳ cognitive performance (2014, background): “Short-wavelength blue light at around 460–480 nm is most effective in inducing circadian phase shifts [3,13,19,32,34].”
Circadian genes, rhythms and the biology of mood disorders. (2007, background): “Recent studies have found that light in the blue spectrum (446–477) outperforms other wavelengths in melatonin suppression, circadian phase shifting, and antidepressant effects (Brainard et al., 2001;Thapan et al., 2001;Lockley et al., 2003;Glickman et al., 2006).”
Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance. (2011, background): “There is ample evidence that a novel, short-wavelength-sensitive photoreceptor system is primarily responsible for a variety of nonvisual light responses, in particular, resetting the timing of the circadian pacemaker, suppressing melatonin production, improving alertness and performance, and elevat”
Investigating daytime effects of correlated colour temperature on experiences, performance, and arousal (2017, positive): “The photopigment melanopsin is most sensitive to wavelengths around 460e480 nm, i.e., to light in the blue part of the spectrum (Berson et al., 2002; Brainard et al., 2001; Panda et al., 2005; Thapan et al., 2001).”
Physiology of circadian entrainment. (2010, background): “Action spectra studies for other end points such as the PLR (289) and the acute photosuppression of serum melatonin levels (47, 461) suggested mediation at least in part by nonvisual photoreceptors.”
Effects of new light sources on task switching and mental rotation performance (2014, background): “But the general picture became more complicated when Brainard et al. (2001) and Thapan, Arendt, and Skene (2001) independently provided unexpected insights into the fundamental processes of a class of ganglion cells in the human retina (i.e., the intrinsically photosensitive retinal ganglion cells,…”
Melatonin as a chronobiotic. (2005, background): “465 nm) blue light is the most effective for both suppression and phase shifting of melatonin.(2,3) In animals and in the right conditions also in humans the profile of melatonin synthesis and secretion is longer during (long) winter nights compared to (short) summer nights.”
Solid-state lighting: an energy-economics perspective (2010, background): “It would also be possible to tailor the spectral match to those (non-retinal) components of the human photoreceptor system responsible for circadian, seasonal and neuroendocrine regulation ( Thapan et al 2001, Rea et al 2010).”