IL-21 and TGF-β are required for differentiation of human TH17 cells

By Li V. Yang, David E. Anderson, C. Baecher-Allan, William D. Hastings, E. Bettelli, M. Oukka, V. Kuchroo, David A. Hafler. Nature, 2008

632 citations recorded by the source corpus.

Subfields: Immunology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “Similar experiments with Rag1-/- mice reconstituted with cells from mice deficient in both RORα and RORγ showed a complete resistance to EAE.”
Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys (2008, background): “, IL-21) could favor the production of IL-17 by memory T cells (30).”
Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. (2012, background): “shown that the combination of TGF-β and IL-21 is sufficient to induce differentiation of human Th17 cells from naïve T cells and, IL-1β and IL-6 are important to enhance the expansion of differentiated and memory Th17 cells.(21) TGF-β can also favor human Th17 differentiation indirectly because of i”
The Microbiome in Infectious Disease and Inflammation (2012, neutral): “Although the cytokine requirements for human Th17 cell differentiation remain to be fully elucidated, similar mechanisms seem to be operative in both humans and mice (148, 149).”