Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects.

By Michael A. Nitsche, David Liebetanz, Andrea Antal, N. Lang, F. Tergau, Walter Paulus. Supplements to Clinical Neurophysiology, 2003

611 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/c79575ea63e6b520e02c86fb5dfdd1ead0dc635f

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Citations in the corpus

Noninvasive Brain Stimulation Improves Language Learning (2008, methodology): “We applied tDCS (20 min, 1 mA) over the posterior part of the left peri-sylvian area of 19 young right-handed individuals while subjects acquired a miniature lexicon of 30 novel object names.”
Clinical Research with Transcranial Direct Current Stimulation (tDCS): Challenges and Future Directions (2011, neutral): “Blocking NMDA receptors abolishes the after-effects of stimulation, whereas enhancement of NMDA receptor efficacy by dcycloserine enhances selectively facilitatory plasticity.(9,54) In contrast, GABAergic modulation with lorazepam results in a delayed then enhanced and prolonged anodal tDCSinduced e”
tDCS-enhanced motor and cognitive function in neurological diseases (2014, neutral): “…polarity, neuronal firing rates increase or decrease, presumably due to DC-induced changes in resting membrane potentials (Liebetanz et al., 2002; Nitsche et al., 2003b), with anodal tDCS in most settings increasing, and cathodal tDCS decreasing motor-cortical excitability (Nitsche and Paulus,…”
A sham‐controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury (2006, background): “…other safety studies using related stimulation protocols, where no change of serum neurone specific enolase concentration – a sensitive marker of neuronal damage, no disturbances of the blood–brain-barrier and no cerebral edemas were found (Nitsche and Paulus, 2001; Nitsche et al., 2003a, 2004).”
Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. (2006, background): “…direct current stimulation (tDCS) influences cognitive functions in healthy volunteers (Antal et al., 2004; Fregni et al., 2005a; Iyer et al., 2005; Nitsche et al., 2003a) and transiently enhances motor performance in patients with chronic stroke (Hummel et al., 2005a; Hummel and Cohen, 2005;…”
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. (2005, background): “In both sessions, currents were turned off slowly over a few seconds, a procedure that does not elicit perceptions (Nitsche et al., 2003c) and that was implemented out of the field of view of the patients.”
Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation (2009, background): “…mediated at least in part by a reduction in GABAergic inhibition in addition to the NMDAreceptor dependency previously demonstrated (Liebetanz et al., 2002; Nitsche et al., 2003b), while the inhibitory effects of cathodal tDCS are mediated by reduction in excitatory glutamatergic neurotransmission.”
Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory (2005, background): “…of excitability-enhancing anodal DC stimulation on simple reaction times and implicit motor learning when the primary motor cortex was stimulated (Nitsche et al. 2003c), as well as improved learning of a visuo-motor coordination task by stimulation of the primary motor area or the visual area V5…”