MicroRNA expression profiles classify human cancers

By Jun Lu, Gad Getz, E. Miska, Ezequiel Alvarez-Saavedra, J. Lamb, David Peck, A. Sweet-Cordero, Benjamin L. Ebert, Raymond Mak, Adolfo A. Ferrando and 4 more. Nature, 2005

9,882 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c7497d6d32d3dd6f893609a17848c807134e1cc4

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Citations in the corpus

MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “Lu and colleagues, by analysing more than 350 tumour samples with a bead-based flow cytometric technique, showed that the small set of poorly differentiated tumours with non-diagnostic histological appearance is much better identified by using the miRNA-based classifier than the PCG mRNA classifie”
Genome-wide identification and analysis of drought-responsive microRNAs in Oryza sativa. (2010, methodology): “The expression result in Populus trichocarpa implied the potential role of ptc-miR474 in the post-transcriptional regulation of organelle gene expression and RNA processing (Lu et al., 2005).”
Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma (2009, background): “Expression profiles of mature miRNA have been published to be capable to classify poorly differentiated tumors.(40) In addition, it has been shown that free circulating miRNAs are detectable in plasma of patients with prostate cancer highlighting their eligibility in clinical practice.”
A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes (2006, background): “…has documented nearly ubiquitous dysregulation of miRNA expression in human cancers (Michael et al., 2003; Calin et al., 2004a; Iorio et al., 2005; Lu et al., 2005; He et al., 2005a; Volinia et al., 2006), miRNA expression patterns are highly specific for cell-type and cellular differentiation…”
A MicroRNA targeting dicer for metastasis control. (2010, background): “…between miR-103/107 and Dicer Levels in Cancer Cell Lines At this point, we were intrigued by the analogy between the effects of miR-103/107 on Dicer function and the hampered maturation of multiple miRNAs observed in human tumors (Lu et al., 2005; Ozen et al., 2008; Ventura and Jacks, 2009).”
Non‐coding RNAs: regulators of disease (2010, background): “Indeed, a signature of as few as 200 miRNAs may be sufficient for cancer classification [198], and it appears that some of the difficulties of early detection associated with colon and other occult cancers may be overcome by profiling miRNAs obtained from patient serum, plasma, saliva and tissues [2”
MicroRNAs in Common Human Diseases (2012, background): “In fact, a more comprehensive miRNA profiling study demonstrated that distinct miRNA expression patterns were specific to various types of cancers and were able to reflect the developmental lineage and differentiation state of tumors [38].”
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (2008, background): “Indeed, down-regulation of a subset of miRNAs is a commonly observed feature of cancers, suggesting these molecules may act as tumor suppressors (6).”
MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. (2008, background): “[11] demonstrated the use of microRNA signatures as an important advance in cancer diagnosis.”
The mammalian ovary from genesis to revelation. (2009, background): “MiRNA profiles reflect the developmental lineages and differentiation states of tumors, sometimes with greater accuracy than mRNA profiles (637).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “New advances have lead to the development of bead-based technology, specifically beadbased flow cytometric expression and bead-array profiling which is highly accurate, specific and feasible to implement within a clinical setting [31, 335].”
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes (2008, background): “Expression profiling studies have detected specific miRNA expression 'signatures' in a variety of human cancers, and miRNA genes are frequently located at genomic regions associated with carcinogenesis, which suggests that miRNA molecules may be involved in cell transformatio”