Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

By Lei Wang, Zhenggang Zhang, Ying Wang, RuiLan Zhang, Michael Chopp. Stroke, 2004

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A Neurovascular Niche for Neurogenesis after Stroke (2006, background): “Animal strains with reduced angiogenesis (Wang et al., 2004a) do not show long-distance neuroblast migration (Komitova et al., 2005).”
Cellular and molecular mechanisms of neural repair after stroke: Making waves (2006, background): “Pharmacological doses of EPO promote cell division and increased neuronal progenitor cells in the SVZ after stroke.(77) Using a conditional knock-out of the EPO receptor (EPOR), researchers recently showed that EPO functions in the normal brain to promote neural stem cell proliferation in the SVZ an”
Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke (2006, background): “... ischemic lesions [34], we found that spontaneous motor recovery after stroke affecting only the striatum occurred over several months concomitantly with striatal neurogenesis (Fig. 6). Also in line with a possible functional role of the new neurons, administration of molecules that promote neura”