NF-kappaB functions as a tumour promoter in inflammation-associated cancer.

By E. Pikarsky, R. Porat, I. Stein, R. Abramovitch, S. Amit, Shafika Kasem, Elena Gutkovich-Pyest, S. Urieli-Shoval, E. Galun, Y. Ben‐Neriah. Nature, 2004

1,243 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c69bf2a3e9e333fd36de743f4758cab6b924f206

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Citations in the corpus

Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “416 Cancer Cell 14, 408–419, November 4, 2008 a2008 Elsevier Inc shown to downregulate the innate immune system and suppress both murine hepatocellular and colon carcinoma (Greten et al., 2004; Maeda et al., 2005; Pikarsky et al., 2004).”
Phosphorylation: Implications in Cancer (2017, background): “Furthermore, deletion of IKKβ and activation of NF-κB has signified its role in tumorigenesis associated with inflammation [59, 60].”
The tumor microenvironment and its role in promoting tumor growth (2008, background): “It has been proposed that the NF-kB pathway plays a key role in activation of signaling in cancer cells as well as tumor-infiltrating leukocytes (Balkwill and Coussens, 2004; Greten et al., 2004; Pikarsky et al., 2004).”
NF‐κB and the link between inflammation and cancer (2012, background): “The major mechanism by which NF-jB was suggested to exert its tumor promoting function in Mdr2 ⁄ ) mice is the suppression of apoptosis (111).”
Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors (2009, unknown): “TNFa has been found to be frequently elevated in cancer and is critical for inflammation-induced cancer through activating NF-kB (Greten et al., 2004; Pikarsky et al., 2004).”
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 (2012, background): “In addition to its role in Abcb4KO chronic liver injury model (Pikarsky et al., 2004), hepatocellular NF-κB also acts a promoter of hepatocarcinogenesis in lymphotoxindriven HCC (Haybaeck et al.”
The H19 Non-Coding RNA Is Essential for Human Tumor Growth (2007, background): “In this specific model of inflammation-induced tumors, we provided evidence that NFkB has a role in HCC progression [9].”
Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “Clinical evidence has long suggested that cancers arise at sites of chronic inflammation and this hypothesis has recently received molecular confirmations in inflammation-associated cancer models [7, 8], which provide in vivo evidences supporting a causal relationship between NF-κBmediated inflammat”