Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

By Wei Zhang, R. Du, Bei Li, Xiao-Shuang Zheng, Xinglou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing-Ru Yan, Zhènglì Shí and 1 more. Emerging Microbes and Infections, 2020

1,720 citations recorded by the source corpus.

ABSTRACT In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral–fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral–fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.

Subfields: Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/c697ba1ee09156a63b1286fdeea2664b86f5aab8

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In Infectious Diseases

Citations in the corpus

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease (2020, background): “Viraemia has been reported in up to 40% of cases [41] with one study showing a strong correlation between serum viral RNA load and ARDS severity [42].”
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SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat (2020, background): “Furthermore, a trend of shift from more oral positive in the collected samples during the early period of patient infection to more anal positive during later period of infection was also found [43].”
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