Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals

By Ivan Seah, Rupesh V Agrawal. Ocular immunology and inflammation, 2020

636 citations recorded by the source corpus.

ABSTRACT In December 2019, a novel coronavirus (CoV) epidemic, caused by the severe acute respiratory syndrome coronavirus – 2 (SARS-CoV-2) emerged from China. This virus causes the coronavirus disease 2019 (COVID-19). Since then, there have been anecdotal reports of ocular infection. The ocular implications of human CoV infections have not been widely studied. However, CoVs have been known to cause various ocular infections in animals. Clinical entities such as conjunctivitis, anterior uveitis, retinitis, and optic neuritis have been documented in feline and murine models. In this article, the current evidence suggesting possible human CoV infection of ocular tissue is reviewed. The review article will also highlight animal CoVs and their associated ocular infections. We hope that this article will serve as a start for further research into the ocular implications of human CoV infections.

Subfields: Neurology, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/bae495562878db6fcb986aabbb85cb36a168f096

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Citations in the corpus

• Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach (2020, background): “…outbreak of severe asymptomatic pneumonia has geographically been associated with the seafood market of south Chinese Wuhan city, primarily designated as 2019 novel coronavirus (Salata, Calistri, Parolin, & Pal (cid:1) u, 2019; Seah & Agrawal, 2020; Hemida & Ba Abduallah, 2020; Chan et al. 2020).”
• Genotype and phenotype of COVID-19: Their roles in pathogenesis (2020, background): “Considering that, in the in vitro study, antiviral therapies are design based on S protein include RBDeACE2 blockers, S cleavage inhibitors, fusion core blockers, neutralizing antibodies, protease inhibitors, S protein inhibitors, and small interfering RNAs.18 There are some recombinant compounds su”