Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

By H. Peinado, M. Quintanilla, A. Cano. Journal of Biological Chemistry, 2003

636 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c690fbfe987d3adecd6fa55bf731acc2d20035b9

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Citations in the corpus

• TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “Studies have shown that in RAS-transformed epithelial tumors, TGF-β significantly increases the expression of VEGF/VEGF-R, which has a powerful effect on capillary formation and migration of endothelial cells, thereby promoting angiogenesis in tumor cells [232].”
• Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. (2006, background): “Snail and Slug also directly inhibit transcription of the epithelial markers such as cytokeratin-8 and cytokeratin-19 (32), desmoplakin, and mucin-1 (33), as well as induce RhoB, a small GTPase-associated with increased motility (34).”
• Epithelial-mesenchymal transition and its implications for fibrosis. (2003, background): “Many studies have generally focused on only one or two event markers (for example, the changes in E-cadherin or Snail expression) and are Table 1 Downloaded from http://www.jci.org on April 27, 2017. https://doi.org/10.1172/JCI20530 not comprehensive.”
• Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. (2008, background): “In various tumor cell lines, TGF-b signaling induces Snail, Slug, and SIP1, which may then proceed to repress the expression of E-cadherin, thereby causing a loss of cell-cell adhesion (Comijn et al., 2001; Peinado et al., 2003).”
• Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer (2003, background): “TGF-β induces expression of both SNAIL and SIP1, which are zinc-finger transcription factors that are known to repress the E-cadherin gen”
• Snail blocks the cell cycle and confers resistance to cell death. (2004, background): “TGF-␤-induced EMT and survival in both hepatocytes and epithelial cells occurs concomitantly with Snail induction (Valdés et al. 2002; Peinado et al. 2003).”
• DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells (2005, background): “Snail is the only protein that has recently been implicated in TGFb-, and ILK- dependent downregulation of E-cadherin (Tan et al., 2001; Peinado et al., 2003).”
• A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. (2010, background): “TGF-b was recently described to block nuclear reprogramming (Maherali and Hochedlinger, 2009) and is a well-known EMT inducer that acts at least in part through activation of Snail (Peinado et al., 2003).”
• The Snail genes as inducers of cell movement and survival: implications in development and cancer (2005, background): “However, cell division is impaired in Snail-expressing epithelial cells that have undergone EMT (Valdés et al., 2002; Peinado et al., 2003; Vega et al., 2004).”
• Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition (2004, background): “Although TGF-β and the oestrogen receptor were shown to regulate Snail transcriptio”