Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis

By C. Ritchlin, S. Haas-Smith, Ping Li, D. Hicks, E. Schwarz. 2003

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Decreased Bacterial Diversity Characterizes an Altered Gut Microbiota in Psoriatic Arthritis and Resembles Dysbiosis of Inflammatory Bowel Disease (2015, background): “First, levels of RANKL have been found to be higher in the sera of PsA patients (39,40), while RANKL expression was also found to be up-regulated in the synovium of PsA patients (41) and in the epidermis of patients with psoriasis (42).”
Cytokines in the pathogenesis of rheumatoid arthritis (2007, background): “TNF also mobilizes CD11b + osteoclast precursors from the bone marro”
Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. (2008, background): “Osteoclast precursors then migrate to the joint where they encounter increased expression of receptor activator of nuclear factor kappa B ligand, which favors the differentiation and activation of osteoclasts.(7) Once formed, osteoclasts are exposed to a variety of activating molecules in the PsA jo”