Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

By Ng Shyh‐Chang, Jason W. Locasale, C. Lyssiotis, Yuxiang Zheng, R. Teo, Sutheera Ratanasirintrawoot, Jin Zhang, T. Onder, J. Unternaehrer, Hao Zhu and 3 more. Science, 2013

595 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c58404c7676f2a2bfc1891eb5a301c10eb11e3fc

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Citations in the corpus

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. (2015, background): “Recently, Shyh-Chang and colleagues demonstrated that threonine metabolism led to accumulation of Ac-CoA in mouse embryonic stem cells (mESCs), fueling synthesis of S-adenosylmethionine (SAM) for histone methylation (Shyh-Chang et al., 2013).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Depletion of threonine from the culture medium or knocking down threonine dehydrogenase (TDH) by shRNAs in mESCs decreased the levels of SAM and H3K4me3, leading to slowed growth and increased differentiation (Shyh-Chang et al., 2013).”
Epigenetic plasticity and the hallmarks of cancer (2017, background): “In stem cells, the maintenance of pluripotency is dependent on finely tuned levels of the methyl donor S-adenosylmethionine and the demethylase cofactor a-KG (77, 78).”
Influence of Metabolism on Epigenetics and Disease (2013, unknown): “More recent work on mouse ESCs has led to the conclusion that TDH-mediated catabolism of threoninemight also be important for maintaining high levels of SAM (Shyh-Chang et al., 2013).”
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism (2015, background): “…methylation modifications on their tails, such as trimethylation at lysine 4, are known to be required for the maintenance of defined cellular states (Benayoun et al., 2014; Ruthenburg et al., 2007) and have been shown to be modulated by metabolism (Shiraki et al., 2014; Shyh-Chang et al., 2013).”
One-Carbon Metabolism in Health and Disease. (2017, background): “The TDH reaction also generates acetyl-CoA, and threonine withdrawal alters histone modification by modulating both SAM and acetyl-CoA levels (Shyh-Chang et al., 2013).”
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination (2016, background): “Pluripotent mESCs are dependent on threonine catabolism by threonine dehydrogenase (TDH) for the synthesis of SAM, which in turn regulates histone methylations that drive ESC self-renewal and pluripotency (Wang et al., 2009; Shyh-Chang et al., 2013).”