Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast.

By G. Ira, A. Malkova, Giordano Liberi, M. Foiani, J. Haber. Cell, 2003

623 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c566a69bd374e3b8d0379779e563d6a35e50760a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. G. Ira
2. Sang Eun Lee
3. W. Chung
4. Zhu Zhu
5. E. Shim
6. Dana Branzei
7. Wolf-Dietrich Heyer
8. M. Foiani

In Molecular Biology

1. G. Ira
2. Dana Branzei
3. Wolf-Dietrich Heyer
4. Xiaolan Zhao
5. M. Špírek
6. Veronika Altmannová
7. L. Krejci
8. M. Foiani

Citations in the corpus

• The Bloom's syndrome helicase suppresses crossing over during homologous recombination (2003, background): “Indeed, recent genetic evidence has revealed that the yeast homologues of BLM and hTOPO IIIα, Sgs1 and Top3 respectively, function in a pathway distinct from synthesis-dependent strand annealing to suppress the formation of crossover products arising from homologous recombination repai”
• Regulation of homologous recombination in eukaryotes (2010, background): “Unlike meiotic HR, dHJs are formed only at low levels during mitotic DSB repair (25), consistent with the low association of mitotic DSB repair with a crossover outcome (78).”
• Homologous recombination and its regulation (2012, background): “Cells expressing a SUMO-deficient mutant of BLM display defects in RAD51 localization to stalled replication forks and failure to induce sister chromatid exchanges (SCEs), indicating that SUMOylation of BLM controls the recruitment and/or retention of RAD51 at damaged replication forks (153).”
• Sources of DNA double-strand breaks and models of recombinational DNA repair. (2014, background): “In contrast, srs2D strains show a 70% drop in viability, which results from a specific deficit in recovering NCO outcomes (Ira et al. 2003).”
• Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double strand break ends (2008, positive): “Mutants with Impaired 50 Strand Resection Show Decreased Gene Conversion Efficiency To test whether resection limited to the vicinity of DSB ends in sgs1D exo1D is sufficient for gene conversion, we used an ectopic recombination assay between a MATa sequence located on chromosome V and a MATa-inc se”
• Regulation of DNA repair throughout the cell cycle (2008, background): “Budding yeast Srs2 has been implicated in channelling DSBR towards synthesis-dependent strand annealing (SDSA), a sub-pathway of HR that leads to non-crossover product”