Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

By W. de Lau, Nick Barker, T. Low, Bonil Koo, Vivian S. W. Li, Hans Teunissen, P. Kujala, A. Haegebarth, P. Peters, M. van de Wetering and 9 more. Nature, 2011

1,270 citations recorded by the source corpus.

Subfields: Hepatology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c52ba19f188c743714ae823112fa10cedd9338e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. Hans Clevers

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. S. Piccolo
4. S. Angers
5. M. Cordenonsi
6. Z. Steinhart
7. W. de Lau
8. W. Peng

Citations in the corpus

• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Cell Stem Cell 9 cells in the murine intestinal and gastric epithelia, which are marked by expression of a leucine-rich G protein-coupled receptor (Lgr5) that functions as an R-spondin receptor (de Lau et al., 2011), divide every 24 hr (Snippert and Clevers, 2011).”
• Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. (2013, background): “A crucial ingredient is the Wnt agonistic R-spondin1, a ligand of Lgr5 (Carmon et al., 2011; de Lau et al., 2011).”
• Wnt signaling in development and tissue homeostasis (2018, background): “However, the precise role of LGR5 and its homologs LGR4/LGR6 remained controversial until the discovery that they function as receptors for four R-spondin secreted proteins, RSPO1-RSPO4 (Carmon et al., 2011; de Lau et al., 2011; Glinka et al., 2011).”
• Identification of multipotent luminal progenitor cells in human prostate organoid cultures (2014, background): “These cultures can be initiated from single Lgr5+ stem cells and are based on the addition of the Lgr4/5 ligand R-spondin1, a potent Wnt pathway agonist (Binnerts et al., 2007; Carmon et al., 2011; de Lau et al., 2011).”
• Prospective derivation of a Living Organoid Biobank of colorectal cancer patients (2015, positive): “R-spondin-1 is the ligand for Lgr5 (Carmon et al., 2011; de Lau et al., 2011).”
• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “The Lgr proteins bind R-spondins through their N-terminal ectodomain and do not appear to utilize G-proteins (Carmon et al., 2011; de Lau et al., 2011).”