A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma.

By Ji-hang Yuan, Fu Yang, F. Wang, Jin‐zhao Ma, Ying-jun Guo, Qi‐fei Tao, Feng Liu, W. Pan, Tian‐tian Wang, Chuan‐chuan Zhou and 7 more. Cancer Cell, 2014

1,481 citations recorded by the source corpus.

Subfields: Cancer Research, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c50c9ed4c48d3714bfc474097c06bd6a21d8ede9

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In Cancer Research

1. David A. Baker
2. Y. Hao
3. Igor Ulitsky
4. P. ten Dijke

In Molecular Biology

1. E. Song
2. David A. Baker
3. Y. Hao
4. Igor Ulitsky
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7. M. Lacouture

Citations in the corpus

• LNCcation: lncRNA localization and function (2021, neutral): “, 2019; Sun and Wong, 2016), as well as in disease (Esteller, 2011; Wang et al., 2013; Yuan et al., 2014).”
• A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. (2015, background): “…shown to regulate important cancer hallmarks, including proliferation (Yang et al., 2013b), apoptosis (Huarte et al., 2010), metastasis (Gupta et al., 2010; Yang et al., 2013a; Yuan et al., 2014), metabolism (Yang et al., 2014), senescence (Yap et al., 2010), and drug-resistance (Fan et al., 2014).”
• Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers (2015, background): “In recent years, increasing evidence has suggested that a novel class of non-coding RNA, long non-coding RNA (lncRNA), is commonly altered at various stages of cancer progression (3,4).”
• Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor (2015, background): “For example, lncRNA-ATB is activated by the type transforming growth factors (TGF- ), to promote invasion of hepatocytes (6).”
• TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “lncRNA-ATB [132] Upregulated by TGF-b and can induce EMT and invasion by acting as ceRNA of miR-200 family and increasing ZEB1/2; promotes organ colonization by binding IL-11 mRNA, autocrine induction of IL-11, and triggering STAT3 signaling.”
• METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing (2017, methodology): “Subcutaneous tumor growth assays, liver metastasis model, and tail vein injection model were performed as described.((18)) Metastases were detected using the IVIS@Lumina II system (Caliper Life Sciences, Hopkinton, MA) 10 minutes after intraperitoneal injection of 4.”
• Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19 (2018, background): “LncRNAs are aberrantly expressed in multiple human cancers, such as colorectal, prostate, breast, liver, brain cancer, renal, and bladder cancer, where they may modulate numerous hallmarks to promote or inhibit CRC development, invasion, and metastasis including proliferation, apoptosis, metastasis ”