METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing

By Jin‐zhao Ma, Fu Yang, Chuan‐chuan Zhou, Feng Liu, Ji-hang Yuan, F. Wang, Tian‐tian Wang, Qing‐guo Xu, Weiping Zhou, Shuhan Sun. Hepatology, 2017

760 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/841e8e882c24ea00079cef3b5a72be2f7fac1964

How researchers see this paper

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In Cancer Research

1. Huayan Duan
2. Yuanyuan An

In Molecular Biology

1. Syuzo Kaneko
2. Masaaki Komatsu
3. Ken Asada
4. Ken Takasawa
5. Xiaolan Deng
6. Amina Bolatkan
7. R. Su
8. Huayan Duan

Citations in the corpus

• RNA N6-methyladenosine modification in cancers: current status and perspectives (2018, background): “, mir-126) processing by interaction with DGCR8.(86) In contrast, Chen et al.”
• Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection (2020, background): “Another study revealed that temperature stress re-localizes METTL3 and the DGCR8 microprocessor complex subunit (DGCR8) to stress-induced genes including heat shock protein 70 (Hsp70), for further degradation [78].”
• RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 (2018, background): “Recently, Ma et al.((38)) reported that METTL14 was suppressed in HCC and impaired primary miRNA processing to promote HCC metastasis.”
• The role of m6A RNA methylation in cancer metabolism (2022, background): “By interacting with DGCR8, METTL14 positively regulates the expression of pre-miR-126, and miR-126 also reversely inhibits the inhibitory effect of METTL14 on tumor cell metastasis [112].”
• The potential role of RNA N6-methyladenosine in Cancer progression (2020, result): “In addition, studies have reported conflicting findings in the same type of cancer; for example, in liver cancer, METTL3 and METTL14 play completely opposite roles in tumor development [105, 157].”
• Functions of N6-methyladenosine and its role in cancer (2019, background): “METTL14 not only enhances the recognition and binding of microprocessor protein DGCR8 to pri-mi126, but also promotes the subsequent processing to mature miRNA [125].”