Equilibrium Contrast Cardiovascular Magnetic Resonance for the Measurement of Diffuse Myocardial Fibrosis: Preliminary Validation in Humans

By A. Flett, M. Hayward, M. Ashworth, Michael S. Hansen, A. Taylor, P. Elliott, C. McGregor, J. Moon. Circulation, 2010

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Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement (2013, background): “ECV has robust histological validation as an ECM measurement which correlates with the collagen volume fraction [24,54,63].”
Calcific aortic stenosis: a disease of the valve and the myocardium. (2012, background): “These are likely to become the preferred method of assessment in AS, having already undergone histological validation and been shown to correlate with symptomatic status (78,79).”
Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing (2013, background): “– can account for spatial variations in coil sensitivity c) T1 mapping: [46-49] – may be helpful in identifying diffuse myocardial fibrosis – may provide a quantitative assessment of the extent of fibrosis”
Assessment of Myocardial Fibrosis with Cardiac Magnetic Resonance (2011, methodology): “(103) validated this method against fibrosis uantification by histology on selective surgical biopsies.”