Assessment of Myocardial Fibrosis with Cardiac Magnetic Resonance
By Mewton Nathan, L. Ying, Croisille Pierre, B. David, Lima João. Journal of the American College of Cardiology, 2011
922 citations recorded by the source corpus.
Diffuse interstitial or replacement myocardial fibrosis are common features of a broad variety of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and is related to adverse cardiovascular events. Cardiac magnetic resonance (CMR) may uniquely characterize the extent of replacement fibrosis and may have prognostic value in various cardiomyopathies. Myocardial T1 mapping is an emerging technique that could improve CMR’s diagnostic accuracy especially for interstitial diffuse myocardial fibrosis. As such, CMR could be integrated in the monitoring and the therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis.
Subfields: Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/2747e3f2bd8f5e8589d73e402daa553e406e5b81
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cardiology and Cardiovascular Medicine
- B. Maron
- M. Maron
- P. Spirito
- Iacopo Olivotto
- J. Udelson
- Francesco Formisano
- H. Rakowski
- John R. Lesser
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Prognostic Value of Quantitative Contrast-Enhanced Cardiovascular Magnetic Resonance for the Evaluation of Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy (2014, background): “In addition, extensive LGE was predictive of adverse LV remodeling with systolic dysfunction (end-stage HCM) and therefore proved to be associated with 2 diverse consequences of HCM. Disclosures None.”
- Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. (2013, neutral): “Emerging T1-mapping CMR techniques offer promise for the evaluation of interstitial fibrosis but remain experimental and require optimization, standardization, and histological validation.(44,45)”
- T1-mapping in the heart: accuracy and precision (2014, background): “However, a single post-contrast T1 measurement has limitations due to a variety of confounding factors [7,8] such as gadolinium clearance rate, time of measurement, injected dose, body composition, and hematocrit.”