Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

By Parag Aggarwal, Jennifer B Hall, C. McLeland, M. Dobrovolskaia, S. McNeil. Advanced Drug Delivery Reviews, 2009

1,728 citations recorded by the source corpus.

Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle–protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution.

Subfields: Biomaterials, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/c4d12a50e4b43990dc78e7c4ac24571ad2d9b475

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Citations in the corpus

Inorganic Nanoparticles in Cancer Therapy (2010, positive): “Upon interaction with cellular millue, certain nanoparticles generate a coating of protein around the surface: the protein “corona” (71).”
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