Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly

By E. Lam, A. Hastie, C. Lin, D. Ehrlich, S. Das, M. Austin, P. Deshpande, H. Cao, Niranjan Nagarajan, M. Xiao and 1 more. Nature Biotechnology, 2012

599 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions (2013, methodology): “These include end sequencing of fosmid clones 6 , fosmid clone dilution pool sequenc ing 9,10 , optical mapping 11–14 and genetic mapping with restriction site– associated DNA tags 15 .”
Overview of Next Generation Sequencing Technologies (2018, background): “…is less time consuming and provides, in addition to fragment sizing information, “roadmap” locations that can be used for building consensus chromosome maps (Bogas et al., 2017; Lam et al., 2012; Mak et al., 2016; Mostovoy et al., 2016; Muller & Westerlund, 2017; Neely, Deen, & Hofkens, 2011).”
Mapping and phasing of structural variation in patient genomes using nanopore sequencing (2017, unknown): “14).”
The Third Revolution in Sequencing Technology. (2018, background): “The results are imaged and aligned to each other, and/or to a reference, to map the locations of the fluorescent signals relative to each other [44].”
The Genome 10K Project: A Way Forward (2015, unknown): “Mapgenerating technologies pioneered by BioNano Genomics, the Irys System, use rare-cut genomic DNA subjected to electrophoretic current to produce physical maps as well (38, 39).”
Epigenomic diversity in a global collection of Arabidopsis thaliana accessions (2016, unknown): “These contigs were built from images of ultra-long fluorescently labeled DNA molecules (Lam et al., 2012).”