Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase.
By F. Wyers, Mathieu Rougemaille, Gwenael Badis, J. Rousselle, M. Dufour, J. Boulay, B. Regnault, Frédéric Devaux, A. Namane, Bertrand Séraphin and 2 more. Cell, 2005
878 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c491075367394eaeff162df70e3a35b862b6dc65
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In Molecular Biology
- John S. Mattick
- David L. Spector
- J. Wilusz
- Marcel E. Dinger
- Hongjae Sunwoo
- Paulo P. Amaral
- G. Natoli
- D. E. Levin
Citations in the corpus
- A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers (2010, background): “However, enhancergenerated transcripts are very unstable, possibly due to a constitutive surveillance by the nuclear exosome [39,40], leading to their complete degradation or the generation of short RNAs [41].”
- Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “4-kb antisense ncRNA that is rapidly degraded by the exosome, a phenomenon that has made detecting such unstable transcripts often difficult, except when RNA decay activities are depleted (Wyers et al. 2005; Davis and Ares 2006; Preker et al. 2008).”
- MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. (2009, positive): “Consistent with this notion, recent studies have revealed a large class of RNAs that are rapidly degraded by the exosome, but can be stabilized by mutations in exosome components (Wyers et al. 2005; Davis and Ares 2006).”
- Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway (2011, background): “…Pol II transcripts, including small nucleolar RNAs, cryptic unstable transcripts, and a few Cell Wall Integrity Signaling Pathway 1161 specialized sites of mRNA attenuation (Ursic et al. 1997; Rasmussen and Culbertson 1998; Steinmetz et al. 2001, 2006; Wyers et al. 2005; Arigo et al. 2006).”