On the Origin of Cancer Metastasis

By T. Seyfried, L. Huysentruyt. Critical reviews in oncogenesis, 2013

1,021 citations recorded by the source corpus.

Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues and to distant organs and is the primary cause of cancer morbidity and mortality. In order to complete the metastatic cascade, cancer cells must detach from the primary tumor, intravasate into the circulatory and lymphatic systems, evade immune attack, extravasate at distant capillary beds, and invade and proliferate in distant organs. Currently, several hypotheses have been advanced to explain the origin of cancer metastasis. These involve an epithelial mesenchymal transition, an accumulation of mutations in stem cells, a macrophage facilitation process, and a macrophage origin involving either transformation or fusion hybridization with neoplastic cells. Many of the properties of metastatic cancer cells are also seen in normal macrophages. A macrophage origin of metastasis can also explain the long-standing “seed and soil” hypothesis and the absence of metastasis in plant cancers. The view of metastasis as a macrophage metabolic disease can provide novel insight for therapeutic management.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/c371e60bf1cb0f81a24fad9b4305ea38cfd2662d

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In Molecular Biology

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Citations in the corpus

• Role of Matrix Metalloproteinases in Angiogenesis and Cancer (2019, background): “Cancer metastasis, the final step of tumor progression and the leading cause of cancer morbidity and mortality, involves the spread of cancer cells from the primary tumor to nearby tissues and distant organs; it is mediated by complex molecular changes of in cell cycle regulation (2, 3).”
• Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433 (2018, neutral): “It is estimated that metastasis is responsible for about 90% of cancer deaths, 39 and it is impossible to deliver light to widely disseminated disease.”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “As one of the hallmarks of cancer, development of metastasis accounts for more than 90% cancer-related deaths [1].”
• Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements (2019, background): “Metastasis involves the spread of cancer cells from the primary tumor to the surrounding tissues and to distant organs, and is the primary cause of morbidity and mortality [45].”